Christina Applegate hospitalized over 30 times with ‘unimaginable’ pain amid MS battle

Christina Applegate revealed she has been hospitalized over 30 times for “unimaginable” pain from gastrointestinal issues amid her battle with multiple sclerosis.

During the one-year anniversary episode her “MesSy” podcast with Jamie-Lynn Sigler, the “Married… with Children” alum detailed her experience with the autoimmune disease after a listener wrote in that she was “throwing up and having diarrhea every single day.”

“This is really important because for three years, since I was diagnosed, I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain that is unimaginable,” Applegate, 53, said on Tuesday’s show.

“They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else,” she continued.

Applegate shared that she thinks she discovered the cause of her symptoms within the last month.

“Now, maybe this isn’t what’s happening, but I’m just gonna tell you this: Talk to your doctor about motility issues, OK? Because one of the things with MS is that it slows down our organs — not completely, but there is a slowing of the function of your organs,” the actress said.

The “Dead to Me” alum further divulged that sometimes her body works double duty when she uses the bathroom.

“I’m gonna be really honest, if I have to poop, I puke. And when I puke, I get all the pain, and then all the things happen,” she said, calling the bodily response “the fight club.”

“So, there’s this really horrible argument,” Applegate explained. “It’s like everyone’s fighting with each other.”

However, the “Bad Moms” star said doctors have told her that the symptoms are unrelated to her MS.

But that hasn’t stopped Applegate from advocating for herself, including going in for a colonoscopy this week and having a “big conversation” with her medical team.

“There’s gotta be a correlation here,” she said on the podcast.

The “Sweetest Thing” actress was diagnosed with MS in early 2021.

In March 2024, she revealed to People that she has to wear diapers “because you probably can’t get to the bathroom in time.”