Leslie Mann Gives Update on Husband Judd Apatow’s Ozempic Journey: ‘Very Proud of the Fact’

Leslie Mann is offering fans an update on her husband Judd Apatow’s journey on the controversial weight loss drug Ozempic.

“He’s on Ozempic, he likes to talk about it, and he has gained, like, 15 pounds in four years,” Mann, 54, said on the Thursday, August 27, episode of Jimmy Kimmel Live!, speaking about her husband’s weight loss journey. “He’s on the highest dose.”

She continued, “He likes to outrun the feeling that you get that Ozempic gives you to stop eating. He likes to, like, override it or outrun it. He’s very proud of the fact that the pharmaceutical companies don’t have control over him. … It’s so weird.”

Ozempic and other similar semaglutides are commonly prescribed to adults who struggle with weight-related conditions, including diabetes, to slim down. Doctors have since warned individuals for using the medication for casual weight loss.

As for Apatow, the 58-year-old filmmaker began taking GLP-1 medications nearly two years ago.

“I am on so much Ozempic right now,” the Knocked Up director said during a 2024 stand-up show in New York City. “I’ve been on it for six months, I’ve gained four pounds. I don’t know how it’s supposed to work. It makes you nauseous, so you don’t want to eat, but I take it as a challenge to eat through the nausea.”

He added at the time, “You know, like, ‘I’m gonna f***ing prove this medicine doesn’t work.’ Sometimes I’ll eat ice cream and shoot myself with Ozempic at the same time just to see who wins the battle. It’s been a draw so far. That experiment cost me $40,000.”

Apatow has previously been candid about his experience trying to lose and maintain his weight.

“[Leslie] put me on the Goop detox diet,” he revealed on Live With Kelly and Ryan in 2017, referring to Gwyneth Paltrow’s lifestyle company. “She has a diet up there [on her website], and I did it, and then suddenly, I looked like Ryan [Seacrest] for a while. I got skinny and handsome. … I’m trying very hard to keep it together.”

At the time, Apatow noted how Mann was “cooking all this food” that he supplemented with a new exercise routine.

“I did a little SoulCycle Hamilton ride the other day, you know how it goes,” he quipped. “I’m trying to ‘cause I hate being healthy, I don’t like it, but I saw an article about ‘dad bods.’ It’s, like, when you work out a little bit and look a little crappy, and my friend sent me an article about it and I clicked the link and there was a picture showing what it was and the picture was of me. I took that as a sign.”

Apatow and the Spa Weekend actress have been married since 1997, during which they welcomed daughters Maude, 28, and Iris, 23.